NEPHRO-News
Background
The peritoneal tissue in patients on
peritoneal dialysis (PD) is exposed to several tons of PD fluid every
year. Basically, the composition of PD fluid mimics the body’s
extracellular fluid, but extra components and other concentrations are
needed to remove fluid and solutes from the blood. The PD procedure by
itself and the adverse effects of some fluid components could be the
reason for the limited long-term survival of the peritoneal membrane as a
dialyzing membrane.
Biocompatibility
Many
studies have demonstrated adverse effects of PD fluids on cells from
the peritoneal cavity. The most obvious incriminating characteristics
are the low pH, the high lactate concentration, the high osmolality and
the high glucose concentration. As if this were not enough, it has also
been demonstrated that during heat sterilization and storage of PD
fluids, some of the glucose is degraded to reactive substances referred
to as glucose degradation products (GDPs).
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Tags: nephro-news
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