NEPHRO-News
Introduction:
Cardiovascular disease (CVD) is the leading cause of mortality among patients with end-stage renal disease (ESRD). Arterial disease and left ventricular hypertrophy (LVH) are the principal risk factors. Arterial disease is due to two frequently associated conditions: atherosclerosis, i.e. intimal disease characterized by presence of plaques and occlusive lesions; and arteriosclerosis, i.e. stiffening of arteries, associated with alterations of the arterial media.
Atherosclerosis
Atherosclerosis refers to the
process of intimal plaque formation or atheroma development. It may be
described as an inflammatory response to oxidized low- density
lipoprotein (LDL)-cholesterol. Atherosclerotic lesions have a patchy
distribution along the artery and cause local stenoses and occlusions.
Since blood flow is dependent on the arterial cross-sectional area, any
decrease in diameter due to such stenosis can lead to impairments of
conduit function and ischemia. Calcification is an intrinsic part of the
process (intimal calcification).
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