NUTRITION-News
Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis.
Knoell
DL, Julian MW, Bao S, et al.
Crit Care Med 2009; 37:1380-8
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH, USA.
In a well controlled model of peritonitis induced by cecal ligation and puncture, Knoell et al. (Knoell DL; Crit Care Med 2009; 37:1380) investigated the influence of zinc (Zn) status on response to sepsis. Mice were assigned to three groups: Control diet, Zn-deficient and Zn-deficient followed by oral Zn supplementation for 3 days. The results are impressing and the authors demonstrate mainly that:
Another animal study (in press) confirms the beneficial effects of supplements in a rabbit model of major trauma and shows that zinc supplementation reduces the activation of NFκB and the inflammatory response, with less organ failures (Yuan XA; J Trace Elem Med Biol 2009 in press).
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